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Iron and TIBC (Total Iron Binding Capacity)

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The Iron and TIBC (Total Iron Binding Capacity) test helps diagnose and monitor various conditions related to iron levels in the body, including iron deficiency anemia, iron overload (hemochromatosis), and other types of anemia. It assesses the body's ability to transport iron, providing key insights into overall iron status and nutritional health.

Quick facts

Sample type

Serum or Plasma (Lithium Heparin)

Turnaround

2–4 business days

Fasting

No Fasting Required

Doctor’s order included

Licensed physician review and requisition included with every test.

Iron and TIBC (Total Iron Binding Capacity)

  • Vitamins & Nutrition
  • General Health & Wellness
    • Cpt Codes
    • 83540
    • 83550

    what is Iron and TIBC (Total Iron Binding Capacity) and why is it important?

    The Iron and TIBC (Total Iron Binding Capacity) test helps diagnose and monitor various conditions related to iron levels in the body, including iron deficiency anemia, iron overload (hemochromatosis), and other types of anemia. It assesses the body's ability to transport iron, providing key insights into overall iron status and nutritional health.

    Consider this test if you are experiencing:

    • Unexplained fatigue, weakness, dizziness, or pale skin, which could be signs of anemia.
    • Abnormal red blood cell parameters (e.g., low MCV or hypochromia) on a routine Complete Blood Count (CBC).
    • A family history of iron overload conditions like hemochromatosis.
    • Symptoms or have medical conditions known to affect iron absorption or metabolism.
    • Pregnancy or heavy menstrual periods, which can increase the risk of iron deficiency.

    This test benefits:

    • Individuals experiencing symptoms commonly associated with iron deficiency, such as persistent fatigue, weakness, pale skin, or shortness of breath.
    • People who may be at risk for iron overload (hemochromatosis) due to genetics or other health conditions.
    • Patients with chronic diseases like kidney failure or inflammatory conditions that can affect iron metabolism.
    • Those undergoing treatment for anemia or iron-related disorders to monitor the effectiveness of therapy.
    • Anyone interested in assessing their overall iron status as part of a general health check-up.

    Commonly Used For Diagnosis Of

    Iron Deficiency Anemia

    This test is pivotal in identifying iron deficiency, a common cause of anemia. Low serum iron, low transferrin saturation, and elevated TIBC (Total Iron Binding Capacity) are classic indicators, reflecting depleted iron stores due to factors like blood loss or inadequate dietary intake. It helps differentiate iron deficiency from other forms of anemia that may present similarly.

    Anemia of Chronic Disease

    In cases of chronic infections, inflammation, or malignancy, iron levels can be low, but the body's iron stores may be adequate. This test helps identify this condition, characterized by low serum iron and low to normal TIBC, indicating a block in iron utilization rather than a true deficiency.

    Hemochromatosis (Iron Overload)

    For individuals with suspected hemochromatosis, a genetic disorder causing excessive iron absorption and accumulation, the Iron and TIBC test is crucial. Markedly elevated serum iron and a very high transferrin saturation (often exceeding 45-50%) are strong indicators, prompting further investigation.

    Sideroblastic Anemia and Hemolytic Anemias

    This panel aids in the diagnosis of sideroblastic anemias, where the body struggles to incorporate iron into hemoglobin, often showing normal to high serum iron and high saturation. Similarly, in hemolytic anemias (red blood cell destruction), elevated serum iron and high saturation can be observed, providing clues to the underlying cause.

    Iron Poisoning and Toxicity

    In acute iron poisoning, dangerously high serum iron levels will be detected. While TIBC may not always be as reliable in severe toxicity, the iron level itself is a critical marker for guiding urgent medical intervention and monitoring iron overload.

    Nutritional Status and Organ Dysfunction

    Beyond specific anemias, this test can reflect overall nutritional status, as transferrin (measured by TIBC) is a protein that transports iron. Low TIBC can be seen in protein depletion due to malnutrition, liver disease, or kidney disease, providing insight into broader systemic health issues.

    Caution

    It is important to discuss your test results with a healthcare provider. Iron levels can be influenced by various factors, including inflammation, chronic diseases, and certain medications, and should be interpreted in the context of your overall health and medical history. This test is one piece of information in a comprehensive health assessment.

    Frequently Ordered Together

    How It Works?

    1
    Add Your Test to Cart and Check out

    once Test Order is received, Our physicians will review your request and email you the easy-to-follow requisition form.

    2
    Locate and Visit Your Nearest Laboratory

    Find the closest partner location—most are within 2–3 miles—and drop by for a quick, no‑appointment blood draw.

    3
    Get your Results Online

    Once your sample is processed, we’ll send your report straight to your inbox within 1–3 business days. Just click the link to view your results anytime.

    4
    Book a Optional Consult

    Have Questions about results? Book a phone or video visit with one of our doctors. They’ll walk you through your report, explain any findings, and recommend next steps