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Apolipoprotein B

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LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.

Quick facts

Sample type

Serum (preferred) or plasma

Turnaround

2–4 business days

Fasting

No Fasting Required

Doctor’s order included

Licensed physician review and requisition included with every test.

Apolipoprotein B

  • Heart Health
  • Diabetes & Blood Sugar
  • General Health & Wellness
    • Cpt Codes
    • 82172

    what is Apolipoprotein B and why is it important?

    LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.

    When to Consider an Apolipoprotein B Test

    • When your standard cholesterol panel (LDL, HDL, triglycerides) results do not fully explain your cardiovascular risk, suggesting a need for a more detailed assessment.
    • If you have a strong family history of early heart disease or unexplained cardiovascular events, even if your traditional lipid numbers appear normal.
    • For individuals with metabolic conditions such as diabetes, metabolic syndrome, or obesity, which significantly increase the risk of atherosclerosis.
    • When evaluating the risk of atherosclerosis, which is the hardening and narrowing of arteries, a key contributor to heart disease.
    • To monitor the effectiveness of lifestyle changes or medications aimed at improving heart health and reducing lipid particle count.

    Who Benefits from an Apolipoprotein B Test?

    • Individuals seeking a more advanced and precise cardiovascular risk assessment beyond standard cholesterol tests.
    • Those with a family history of early heart disease or unexplained cardiovascular events, providing crucial insights into genetic predispositions.
    • Patients with existing metabolic conditions such as diabetes, metabolic syndrome, or obesity, who are at higher risk for cardiovascular complications.
    • Anyone looking to closely monitor the effectiveness of lipid-lowering therapies or lifestyle interventions aimed at improving heart health.
    • People who have discordance between their LDL cholesterol and other risk factors, where ApoB can offer clarity.

    Commonly Used For Diagnosis and Risk Assessment of:

    • Atherosclerosis and Cardiovascular Disease (CAD): The ApoB test is a powerful predictor of atherosclerotic cardiovascular disease, including heart attack, stroke, and peripheral artery disease. It directly reflects the number of atherogenic particles that can penetrate the arterial wall and contribute to plaque formation.
    • Risk Stratification in Metabolic Syndrome and Diabetes: Patients with metabolic syndrome, insulin resistance, or type 2 diabetes often have a higher number of small, dense LDL particles, which are more easily measured by ApoB than by standard LDL-C. This test helps identify elevated risk even when LDL-C levels appear borderline or normal.
    • Familial Hypercholesterolemia and Other Genetic Lipid Disorders: In some inherited conditions affecting lipid metabolism, ApoB can provide a clearer picture of cardiovascular risk than traditional lipid panels, aiding in early diagnosis and aggressive management.
    • Evaluating Treatment Efficacy: ApoB levels can be used to monitor the effectiveness of lipid-lowering therapies, such as statins, fibrates, or PCSK9 inhibitors, and lifestyle interventions aimed at reducing the burden of atherogenic particles.
    • Residual Cardiovascular Risk: For individuals who have achieved target LDL-C levels but still have significant cardiovascular risk, an elevated ApoB can indicate residual risk, prompting more intensive management strategies.

    Caution

    Important Considerations

    It is crucial to discuss your Apolipoprotein B test results with your healthcare provider. They can interpret the findings in the context of your overall health, medical history, and other risk factors, guiding you on the best course of action for managing your cardiovascular health. This test is a valuable tool for cardiovascular risk assessment and should not be used as a sole diagnostic criterion. Always consult with a qualified medical professional for diagnosis and treatment decisions.

    Frequently Ordered Together

    How It Works?

    1
    Add Your Test to Cart and Check out

    once Test Order is received, Our physicians will review your request and email you the easy-to-follow requisition form.

    2
    Locate and Visit Your Nearest Laboratory

    Find the closest partner location—most are within 2–3 miles—and drop by for a quick, no‑appointment blood draw.

    3
    Get your Results Online

    Once your sample is processed, we’ll send your report straight to your inbox within 1–3 business days. Just click the link to view your results anytime.

    4
    Book a Optional Consult

    Have Questions about results? Book a phone or video visit with one of our doctors. They’ll walk you through your report, explain any findings, and recommend next steps