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UberTests

Active Vitamin D (Calcitriol)

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This test measures Calcitriol (1,25 di-OH Vitamin D), the active form of Vitamin D. It is used to aid in the diagnosis of primary hyperparathyroidism, hypoparathyroidism, pseudohypoparathyroidism, renal osteodystrophy, and vitamin D-resistant rickets.

Quick facts

Sample type

Serum or plasma

Turnaround

2–4 business days

Fasting

No Fasting Required

Doctor’s order included

Licensed physician review and requisition included with every test.

Active Vitamin D (Calcitriol)

  • Bone Health
  • Endocrine Health
  • Nutrition & Micronutrients
    • Cpt Codes
    • 82652

    what is Active Vitamin D (Calcitriol) and why is it important?

    This test measures Calcitriol (1,25 di-OH Vitamin D), the active form of Vitamin D. It is used to aid in the diagnosis of primary hyperparathyroidism, hypoparathyroidism, pseudohypoparathyroidism, renal osteodystrophy, and vitamin D-resistant rickets.

    When to Consider the Calcitriol (1,25 di-OH Vitamin D) Test

    You might consider this test if you are experiencing symptoms or have conditions such as:

    • Unexplained bone pain, muscle weakness, or bone deformities.
    • Symptoms suggestive of high or low calcium levels, such as fatigue, nausea, constipation (high calcium) or muscle cramps, tingling, and numbness (low calcium).
    • Known kidney disease, especially if bone health issues are present.
    • Symptoms consistent with overactive or underactive parathyroid glands.
    • If your 25-hydroxy Vitamin D levels are normal, but you still exhibit symptoms of vitamin D deficiency or bone health issues, indicating a potential problem with vitamin D activation.

    Who Benefits from the Calcitriol (1,25 di-OH Vitamin D) Test?

    Individuals who may benefit from the Active Vitamin D (Calcitriol) test include:

    • Those with suspected disorders of calcium or phosphate metabolism.
    • Patients with kidney disease (renal osteodystrophy), as kidney function impacts active vitamin D production.
    • Individuals being evaluated for parathyroid gland disorders (hyperparathyroidism or hypoparathyroidism).
    • Children or adults with suspected bone conditions like rickets or osteomalacia, especially when standard vitamin D tests (25-OH Vitamin D) don't fully explain symptoms.

    Commonly Used For Diagnosis Of

    • Primary Hyperparathyroidism: To assess the overactivity of parathyroid glands, which can lead to high calcium levels and increased calcitriol production.
    • Hypoparathyroidism: To investigate underactive parathyroid glands, which may result in low calcium levels and impaired calcitriol synthesis.
    • Pseudohypoparathyroidism: A condition where the body does not respond normally to parathyroid hormone, affecting calcium regulation and potentially calcitriol levels.
    • Renal Osteodystrophy: To evaluate bone complications associated with chronic kidney disease, as impaired kidney function directly affects calcitriol production.
    • Vitamin D-Resistant Rickets: To identify types of rickets that do not respond to standard vitamin D supplementation, often due to issues with calcitriol metabolism or action.
    • Disorders of Calcium and Phosphate Metabolism: To pinpoint imbalances in these crucial minerals, which calcitriol actively regulates.

    Caution

    Important Considerations

    It is important to note that the 25-hydroxy Vitamin D test is generally considered the best indicator of overall vitamin D status. This Calcitriol (1,25-dihydroxy Vitamin D) test provides specific information about the active form of vitamin D, which is crucial for certain conditions but may not reflect your total vitamin D reserves. Always consult with a healthcare provider to interpret your results in the context of your complete medical history and other lab findings.

    Frequently Ordered Together

    How It Works?

    1
    Add Your Test to Cart and Check out

    once Test Order is received, Our physicians will review your request and email you the easy-to-follow requisition form.

    2
    Locate and Visit Your Nearest Laboratory

    Find the closest partner location—most are within 2–3 miles—and drop by for a quick, no‑appointment blood draw.

    3
    Get your Results Online

    Once your sample is processed, we’ll send your report straight to your inbox within 1–3 business days. Just click the link to view your results anytime.

    4
    Book a Optional Consult

    Have Questions about results? Book a phone or video visit with one of our doctors. They’ll walk you through your report, explain any findings, and recommend next steps