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The HFE gene test looks for common changes in a gene that helps control iron. Some changes can raise the chance of iron overload. This page explains who may need the test and how to read results in simple terms.
Last reviewed: September 2025
Ferritin, TSAT, iron panel, CBC, and more.
What is the HFE Gene Test?
This is a blood or saliva test. It checks for common HFE changes called C282Y and H63D. Some people with these changes can build up too much iron over time.
Related reading: High Ferritin · Transferrin Saturation (TSAT) · Hemochromatosis Guide
When to Get Tested
- Ferritin is high and TSAT is high on repeat tests
- You have a parent, brother, or sister with hemochromatosis
- You have signs that fit iron overload and your clinician suggests it
What Results Can Mean
- C282Y/C282Y (two copies): higher chance of iron overload
- C282Y/H63D (one of each): mixed risk; watch labs over time
- H63D/H63D or single copies: lower chance; labs still matter
- No common changes: iron overload is less likely from HFE, but other causes are possible
What to Do After Results
- Keep up with labs like ferritin, TSAT, and CBC
- Ask about treatment plans if iron stays high
- Share results with close family if advised
Family and Privacy
- Your clinician can guide if family should be tested
- Keep your report in a safe place
- Ask about how the lab stores your genetic data
FAQs
Does a gene change mean I will get sick?
Not always. Many people with a gene change never get iron overload. Your lab numbers and symptoms matter.
Can I lower risk if I have a gene change?
Follow your plan. Keep up with labs. Do not take iron unless told to do so.
Will insurance cover this test?
It depends on your plan and your location. Ask your provider.
Educational content only. Not medical advice.